I've never tried this before and not sure if it can be done? I just moved and i'm wanting to do a lifelong build, I've read so much out there but nothing seems to answer my basic question. is it possible to build a track from tabletop to ceiling height without issues? I've read a lot on grades, but before I go to cutting up a new house to do a room to room track and spend a small fortune is doing so I wanted to know if anyone else has ever tried this and issues they ran into. looking to build something that's user friendly, build, set speeds, walk away for hours and let it run. the idea is a dual track system with trains running in both directions. I'm concerned when the train actually does the decent back to table level, does it need to be "babysitted" to keep it on a rail? as most of you can tell I'm new at this, and my questions may sound "dumb" to you. but I'm wanting to learn before I invest. any and all suggestions, comments are welcome!

Thanks for the advice Larry, I'm not sure what you mean by "phasing" the transformers together, but I'll did into it. ..and that leads me to another question, when purchasing transformers do they all have to match in wattage? I've seen several used on auction sites thats reasonable, but haven't pulled the trigger yet because I don't know exactly what I need yet. I've read that multiple power blocks set up in your configuration is the way to do this, and inexpensive phone wire for the entire loop, If I understand what I'm reading right, I'm going to need a transformer for every 10-12 feet of track? thats a butload of transformers! ..and in your personal opinion would you stay away from "used" and just by new? wattage? brand? 

Cutnshoots
Hello & Welcome to the Forum.
Table top to ceiling layout's are common, especially in large scale indoor layouts..  They are/were seen in restraunts.
Normally you want to use a 2% grade for your average locomotive & consist.
With traction tires and a short consist 4 to 6% grade is feasable.
With a geared locomotive (Climax, Heisler, etc) you might be able to climb an 8% grade with a light consist.

Happy Rails!
dave